Plpro/papain-like protease Proteins, cDNA Clones Research Reagents

All Plpro/papain-like protease reagents are produced in house and quality controlled, including 31 Plpro/papain-like protease Gene, 2 Plpro/papain-like protease Protein. All Plpro/papain-like protease reagents are ready to use.

Plpro/papain-like protease Protein (2)

    Plpro/papain-like protease cDNA Clone (31)

    JX869059.2 (nt4725-5684)

    In expression vector

    SARS-CoV, isolate WH20

    In expression vector

    Plpro/papain-like protease Background

    The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.

    Plpro/papain-like protease References

    • Yahira M. Báez-Santos.The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds. Antiviral Research.2015

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