Prostasin/PRSS8 Proteins, Antibodies, cDNA Clones Research Reagents

PRSS8 (Serine Protease 8) is a protein coding gene located on human chromosome 16p11.2. PRSS8 is also known as CAP1 and PROSTASIN. The human PRSS8 gene encodes a 36431 Da protein containing 343 amino acids. The PRSS8 protein is broadly expressed in small intestine, colon and other tissues. Among its related pathways are Keratinization and Developmental Biology. PRSS8 is related to serine-type endopeptidase activity and serine-type peptidase activity. PRSS8 is associated with some diseases, including Pseudohypoaldosteronism and Ichthyosis, Follicular.

Prostasin/PRSS8 Protein (3)

    Prostasin/PRSS8 Antibody (5)

      Prostasin/PRSS8 cDNA Clone (27)


      In cloning vector

      Prostasin/PRSS8 Lysate (3)

        Prostasin/PRSS8 Background

        Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. Besides, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.

        Prostasin/PRSS8 References

        • Yu J.X., et al.,(1995), Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA. J. Biol. Chem. 270:13483-13489.
        • Ota T., et al., (2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.
        • Martin J., et al.,(2004), The sequence and analysis of duplication-rich human chromosome 16.Nature 432:988-994.

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