S100A6 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

S100A6 (S100 Calcium Binding Protein A6) is a protein coding gene located on human chromosome 1q21.3. S100A6 is also known as 2A9, PRA, 5B10, CABP, CACY and S10A6. The human S100A6 gene encodes a 10180 Da protein containing 90 amino acids. The S100A6 protein is broadly expressed in colon, lung and other tissues. Among its related pathways are Gastric Cancer Network 2 and Ca, cAMP and Lipid Signaling. S100A6 is related to calcium ion binding and calcium-dependent protein binding. S100A5 is an important paralog of S100A6 gene. S100A6 is associated with some diseases, including Melanoma In Congenital Melanocytic Nevus and Pilomatrixoma.

S100A6 Protein (3)

    S100A6 Antibody (7)

      S100A6 ELISA Kit & Match Antibody ELISA Pair Set (1)

      S100A6 cDNA Clone (43)

      S100A6 Lysate (1)

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        S100A6 Background

        S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. S100A6 (S100 calcium-binding protein A6) is a member of the S100 family of proteins, and functions in prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of S100A6 have been implicated in melanoma.

        S100A6 References

        • Schäfer, B.W. et al., 1996, Trends Biochem. Sci. 21 (4): 134-140.
        • Donato,R. et al., 2003, Microsc. Res. Tech. 60 (6): 540-551.
        • Nowotny, M. et al., 2003, J. Biol. Chem. 278 (29): 26923-26928.
        • Nonaka D, et al., 2008, J. Cutan. Pathol. 35 (11): 1014-1019.
        • Marenholz, I. et al., 2004, Biochem. Biophys. Res. Commun. 322 (4): 1111-22. 

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