S100P Proteins, Antibodies, cDNA Clones Research Reagents

S100P (S100 Calcium Binding Protein P) is a protein coding gene located on human chromosome 4p16.1. S100P is also known as MIG9. The human S100P gene encodes a 10400 Da protein containing 95 amino acids. The S100P protein is biasedly expressed in stomach, bone marrow and other tissues. Among its related pathways are Innate Immune System and Ca, cAMP and Lipid Signaling. S100P is related to calcium ion binding and calcium-dependent protein binding. S100A1 is an important paralog of S100P gene. S100P is associated with some diseases, including Geographic Tongue and Atrophic Glossitis.

S100P Protein (2)

    S100P Antibody (5)

      S100P cDNA Clone (2)

      NM_005980.2

      In expression vector

      S100P Background

      Protein S100-P, also known as Protein S100-E, S100 calcium-binding protein P, S100P and S100E, is a nucleus and cytoplasm protein that belongs to the S-100 family. S100P / S100E contains twoEF-hand domains. S100P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. S100P / S100E overexpression can upregulate androgen receptor expression and thereby promote prostate cancer progression by increasing cell growth. S100P / S100E may directly confer resistance to chemotherapy. S100P / S100E induction may be considered an important step in the initial stage of lung adenocarcinomas, whereas its downregulation in advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role. S100P / S100E plays a major role in the aggressiveness of pancreatic cancer that is likely mediated by its ability to activate RAGE. Interference with S100P / S100E may provide a novel approach for treatment of pancreatic cancer. S100P / S100E could be considered a potential drug target or a chemosensitization target, and could also serve as a biomarker for aggressive, hormone-refractory and metastatic prostate cancer.

      S100P References

      • Arumugam,T. et al., 2005, Clin Cancer Res. 11 (15): 5356-64.
      • Basu,G.D. et al., 2008, Int J Cancer. 123 (2): 330-9.
      • Rehbein,G. et al., 2008,Int J Mol Med. 22 (1): 69-77.
      • Heil,A. et al., 2011, J Biol Chem. 286 (9): 7227-38.

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