SEMA3A Proteins, Antibodies, cDNA Clones Research Reagents

SEMA3A (Semaphorin 3A) is a protein coding gene located on human chromosome 7q21.11. SEMA3A is also known as HH16, SemD, COLL1, SEMA1, SEMAD, SEMAL, coll-1, Hsema-I, SEMAIII and Hsema-III. The human SEMA3A gene encodes an 88889 Da protein containing 771 amino acids. The SEMA3A protein is broadly expressed in placenta, gall bladder and other tissues. Among its related pathways are Semaphorin interactions and Guidance Cues and Growth Cone Motility. SEMA3A is related to chemorepellent activity. SEMA3D is an important paralog of SEMA3A gene. SEMA3A is associated with some diseases, including Hypogonadotropic Hypogonadism 16 With Or Without Anosmia and Kallmann Syndrome.

SEMA3A Protein (3)

    SEMA3A Antibody (1)

      SEMA3A cDNA Clone (26)

      NM_006080.2
      NM_009152.3

      SEMA3A Lysate (3)

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        SEMA3A Background

        Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 5 aa Sema domain. They are best characterized in relation to axon guidance during development of the nervous system. The functions of Semaphorins 3A (SEMA3A) are mediated primarily through binding to the Neuropilin-1 (Npn-1) and Plexin-A1 coreceptor complex. Neuropilins lack a signaling-competent cytoplasetmic domain and ensure semaphorin binding, whereas the transmembrane receptor plexin mediates the intracellular response. As the first identified vertebrate semaphorin, SEMA3A functions either as a chemorepulsive agent inhibiting axonal outgrowth, or as a chemoattractive agent stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Its overexpression is associated with schizophrenia which is seen in various human tumor cell lines, and aberrant release is associated with the progression of Alzheimer's disease

        SEMA3A References

        • Giordano,A. et al., 2003, J Neurocytol.32(4):345-352.
        • Good, P. F. et al., 2005, J. Neurochem.91(3): 716-736.
        • Gu, C. et al., 2005, Science.307(5707): 265–268.
        • Chadborn,N.H. et al., 2006, J Cell Sci.119(Pt 5):951-957.
        • Schmidt,E.F. et al., 2007, Adv Exp Med Biol.600:1-11.

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