Serpina3n Proteins, cDNA Clones Research Reagents

Murine serpina3n (SA3N) is a serine protease inhibitor that is highly expressed in the brain, testes, spleen, lung and thymus and has a high degree of homology with the human α1-antichymotrypsin (ACT). Although in humans there is a single-gene coding for ACT, in mice, repeated duplication has resulted in a cluster of 13 closely related genes at the same locus. SA3N was found to be a potent extracellular inhibitor of Granzyme B (GZMB). Serpina3n plays significant roles ranging from complement cascade, apoptosis, wound healing to Alzheimer by inhibiting a wide range of proteases.

Serpina3n Protein (1)

    Serpina3n cDNA Clone (14)


    In cloning vector

    Serpina3n qPCR Primer (1)

    Serpina3n Lysate (1)

      Serpina3n Background

      Serpina3n may represent a circulating biomarker of muscle atrophy associated with GC and, broadly, a reflection of dynamic changes in muscle mass. Serpina3n blocks endogenous increases in the activity of select skeletal muscle resident proteases during injury or dystrophic disease, which stabilizes the sarcolemma leading to less myofiber degeneration and increased regeneration.

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