SerpinB3 Proteins, Antibodies, cDNA Clones Research Reagents

SERPINB3 (Serpin Family B Member 3) is a protein coding gene located on human chromosome 18q21.33. SERPINB3 is also known as SCC, T4-A, SCCA1, SSCA1, SCCA-1, HsT1196 and SCCA-PD. The human SERPINB3 gene encodes a 44565 Da protein containing 390 amino acids. The SERPINB3 protein is restrictedly expressed toward esophagus. Among its related pathways are Innate Immune System and Amoebiasis. SERPINB3 is related to serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity. SERPINB4 is an important paralog of SERPINB3 gene. SERPINB3 is associated with some diseases, including Lung Cancer and Cervical Squamous Cell Carcinoma.

SerpinB3 Protein (1)

    SerpinB3 Antibody (5)

      SerpinB3 cDNA Clone (15)

      SerpinB3 qPCR Primer (1)

      SerpinB3 Lysate (1)

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        SerpinB3 Background

        SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be secreted in plasma by cancerous cells but at a low level. SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells. It may act as a protease inhibitor to modulate the host immune response against tumor cells and may be involved in the malignant behavior of squamous cell carcinoma cells.

        SerpinB3 References

        • Schneider SS, et al. (1995) A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci. 92(8):3147-51.
        • Suminami Y, et al.. (1992) Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. Biochem Biophys Res Commun. 181(1):51-8.
        • Mino-Miyagawa N, et al. (1990) Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus. Cancer. 66(7):1505-12.

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