SMYD3 Proteins, cDNA Clones Research Reagents

SMYD3 (SET And MYND Domain Containing 3) is a protein coding gene located on human chromosome 1q44. SMYD3 is also known as KMT3E, ZMYND1, ZNFN3A1 and bA74P14.1. The human SMYD3 gene encodes a 49097 Da protein containing 428 amino acids. The SMYD3 protein is ubiquitously expressed in thyroid, brain and other tissues. Among its related pathways are Lysine degradation and PKMTs methylate histone lysines. SMYD3 is related to RNA polymerase II core promoter sequence-specific DNA binding and RNA polymerase II complex binding. SMYD1 is an important paralog of SMYD3 gene. SMYD3 is associated with some diseases, including Cerebellar Ataxia, Nonprogressive, With Mental Retardation and Renal Wilms' Tumor.

SMYD3 Protein (2)

    SMYD3 cDNA Clone (45)

    SMYD3 Lysate (2)

      SMYD3 Background

      SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional regulation in human carcinogenesis. It activates the transcription of a set of downstream genes. Of these downstream genes, there are several oncogenes and genes associated with cell adhesion (including those of N-Myc, CrkL, Wnt1b, L-selectin, CD31 and galectin-4), which have been shown to have effects on cell viability, adhesion, migration and metastasis. Increased SMYD3 expression is essential for the proliferation of breast cancer cells. SMYD3 may be a promising new target of therapeutic intervention for the treatment of cancers or other pathological processes associated with cell adhesion and migration.

      SMYD3 References

      • Hamamoto, R. et al., 2006, Cancer Sci. 97 (2): 113-8.
      • Luo, XG. et al., 2007, J Biosci Bioeng. 103 (5): 444-50.
      • Wang, XQ. et al., 2007, Exp Oncol. 29 (1): 71-3.
      • Silva, FP. et al., 2008, Oncogene. 27 (19): 2686-92.

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