SPINK1 Antibodies, cDNA Clones Research Reagents

SPINK1 (Serine Peptidase Inhibitor Kazal Type 1, also known as TCP; PCTT; PSTI; TATI; Spink3), located on 5q32, is a Protein Coding gene. The gene produces an 8507 Da protein composed of 79 amino acids. The SPINK1 gene encodes pancreatic secretory trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. SPINK1 plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. Diseases such as Pancreatitis, Hereditary, and Tropical Calcific Pancreatitis are associated with SPINK1.

SPINK1 Antibody (1)

    SPINK1 cDNA Clone (25)

    SPINK1 qPCR Primer (1)

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    SPINK1 Background

    Trypsin activity is properly suppressed by pancreatic secretory trypsin inhibitor (PSTI), which is also known as serine protease inhibitor Kazal type 1 (SPINK1), thereby preventing damage to pancreatic acinar cells as the first line of defense. SPINK1 is a 6420 Da peptide produced by the pancreas, but also by several other tissues and many tumors. SPINK1, which is an acute-phase response protein plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cell growth, migration, and invasion. Some mutations of the SPINK1 gene, like the one causing amino acid change N34S, have been shown to confer susceptibility to recurrent or chronic pancreatitis. Detection of such variants is therefore of clinical utility. SPINK1 overexpression defines the second most recurrent and aggressive prostate cancer subtype.

    SPINK1 References

    • Xu L, et al. (2018) Spink1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker. BMB Rep 51 (12): 648-653.
    • Ravela S, et al. (2018) An immunocapture-lc-ms-based assay for serum spink1 allows simultaneous quantification and detection of spink1 variants. Anal Bioanal Chem 410 (6): 1679-1688.
    • Buchholz I, et al. (2020) The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor kazal type 1 (spink1) and its n34s variant. Biochim Biophys Acta Proteins Proteom 1868 (1): 140281.
    • Bhatia V, et al. (2019) Epigenetic silencing of mirna-338-5p and mirna-421 drives spink1-positive prostate cancer. Clin Cancer Res 25 (9): 2755-2768.

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