Src Proteins, Antibodies, cDNA Clones Research Reagents

SRC (SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase) is a protein coding gene located on human chromosome 20q11.23. SRC is also known as ASV, SRC1, THC6, c-SRC, and p60-Src. The human SRC gene encodes a 59835 Da protein containing 536 amino acids. The SRC protein is ubiquitously expressed in stomach, testis and other tissues. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Negative regulation of MAPK pathway. SRC is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. YES1 is an important paralog of SRC gene. SRC is associated with some diseases, including Thrombocytopenia 6 and Myelofibrosis.

Src Protein (2)

    Src Antibody (2)

      Src cDNA Clone (44)

      NM_005417.3
      XM_017028024.1

      In expression vector

      NM_001025395.2
      NM_009271.3

      Src Lysate (2)

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        Src Background

        Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.

        Src References

        • Juan Ma. et al., 2003, Neuroscience Letters. 348 (3): 185-189.
        • Czernilofsky AP. et al., 1980, Nature. 287: 198-203.
        • Beischlag TV. et al., 2002, Molecular and cellular biology. 22 (12): 4319-33.

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