TBG Proteins, Antibodies, cDNA Clones Research Reagents

SERPINA7 (Serpin Family A Member 7) is a protein coding gene located on human chromosome Xq22.3. SERPINA7 is also known as TBG and TBGQTL. The human SERPINA7 gene encodes a 46325 Da protein containing 415 amino acids. The SERPINA7 protein is restrictedly expressed toward liver. Among its related pathways are Aldosterone synthesis and secretion. SERPINA7 is related to serine-type endopeptidase inhibitor activity and hormone binding. SERPINA9 is an important paralog of SERPINA7 gene. SERPINA7 is associated with some diseases, including Thyroxine-Binding Globulin Quantitative Trait Locus and Hyperthyroxinemia.

TBG Protein (2)

    TBG Antibody (7)

      TBG cDNA Clone (26)

      NM_000354.4
      NM_177920.4

      TBG Lysate (2)

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        TBG Background

        Thyroxine-binding globulin, also known as T4-binding globulin, Serpin A7 and TBG, is a secreted protein that belongs to the serpin family. TBG is synthesized primarily in the liver as a 54 kDa protein.TBG is genomically a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 and T3, TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone.

        TBG References

        • Flink I.L., et al.,(1986), Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases. Proc. Natl. Acad. Sci. U.S.A. 83:7708-7712.
        • Akbari M.T., et al., (1993), The structure of the human thyroxine binding globulin (TBG) gene.Biochim. Biophys. Acta 1216:446-454.
        • Hayashi Y., et al.,(1993), Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation.Mol. Endocrinol. 7:1049-1060.

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