TEM7 (Protein | Antibody | cDNA Clone | ELISA Kit)

All TEM7 reagents are produced in house and quality controlled, including 9 TEM7 Antibody, 1 TEM7 ELISA, 13 TEM7 Gene, 1 TEM7 Lysate, 1 TEM7 Protein. All TEM7 reagents are ready to use.

TEM7 Protein (1)

    TEM7 Antibody (9)

      TEM7 ELISA Kit & Match Antibody ELISA Pair Set (1)

      TEM7 cDNA Clone (13)

      XM_005583997.1

      TEM7 Lysate (1)

        TEM7 Background

        Plexin domain-containing protein 1, also known as tumor endothelial marker 3, tumor endothelial marker 7 and PLXDC1 and TEM3, is a secreted, cytoplasm and single-pass type I membrane protein which belongs to theplexin family. PLXDC1 / TEM3 is detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. It is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. PLXDC1 / TEM3 is not detectable in endothelial cells from normal tissue. PLXDC1 / TEM3 plays a critical role in endothelial cell capillary morphogenesis. PLXDC1 / TEM3 may play a significant role in the proliferation and maintenance of neovascular endothelial cells in the formation of fibrovascular membranes (FVMs). PLXDC1 / TEM3 may be a molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy (PDR). PLXDC1 / TEM3 interacts with NID1. It may also interact with CTTN.

        TEM7 References

        • Beaty,R.M. et al., 2007,J Neurooncol. 81 (3):241-8.
        • Miller,S.F. et al., 2007, Gene Expr Patterns. 7 (5):635-44.
        • Yamaji,Y. et al., 2008, Invest Ophthalmol Vis Sci. 49 (7):3151-7.

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