TFPI2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TFPI2 (Tissue Factor Pathway Inhibitor 2) is a protein coding gene located on human chromosome 7q21.3. TFPI2 is also known as PP5, REF1 and TFPI-2. The human TFPI2 gene encodes a 26934 Da protein containing 235 amino acids. The TFPI2 protein is biasedly expressed in placenta and fat. Among its related pathways are Cell adhesion_Plasmin signaling and Formation of Fibrin Clot (Clotting Cascade). TFPI2 is related to serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. TFPI is an important paralog of TFPI2 gene. TFPI2 is associated with some diseases, including Fibrosarcoma and Choriocarcinoma.

TFPI2 Protein (3)

    TFPI2 Antibody (6)

      TFPI2 ELISA Kit & Match Antibody ELISA Pair Set (2)

      TFPI2 cDNA Clone (28)

      TFPI2 Lysate (3)

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        TFPI2 Background

        Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in various adult human tissues, such as the liver, skeletal muscle, heart, kidney, and pancreas. The expression of TFPI2 in tumors is inversely related to an increasing degree of malignancy, which may suggest a role for TFPI2 in the maintenance of tumor stability and inhibition of the growth of neoplasms. TFPI2 inhibits the tissue factor/factor VIIa (TF/VIIa) complex and a wide variety of serine proteinases including plasmin, plasma kallikrein, factor XIa, trypsin, and chymotrypsin. TFPI2 is involved in regulating pericellular proteases implicated in a variety of physiologic and pathologic processes including cancer cell invasion, vascular inflammation, and atherosclerosis. TFPI2 has also been shown to induce apoptosis and inhibit angiogenesis, which may contribute significantly to tumor growth inhibition.

        TFPI2 References

        • Peerschke EI, et al. (2004) Tissue factor pathway inhibitor-2 (TFPI-2) recognizes the complement and kininogen binding protein gC1qR/p33 (gC1qR): implications for vascular inflammation. Thromb Haemost. 92(4): 811-9.
        • Rollin J, et al. (2005) Expression and methylation status of tissue factor pathway inhibitor-2 gene in non-small-cell lung cancer. Br J Cancer. 92(4): 775-83.
        • Chand HS, et al. (2005) Structure, function and biology of tissue factor pathway inhibitor-2. Thromb Haemost. 94(6): 1122-30.
        • Sierko E, et al. (2007) The role of tissue factor pathway inhibitor-2 in cancer biology. Semin Thromb Hemost. 33(7): 653-9.

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