TGFBR2 Proteins, Antibodies, cDNA Clones Research Reagents

TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a protein coding gene located on human chromosome 3p24.1. TGFBR2 is also known as AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TBRII, TBR-ii, TGFR-2 and TGFbeta-RII. The human TGFBR2 gene encodes a 64568 Da protein containing 567 amino acids. The TGFBR2 protein is ubiquitously expressed in fat, lung and other tissues. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Transcriptional misregulation in cancer. TGFBR2 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. ACVR2A is an important paralog of TGFBR2 gene. TGFBR2 is associated with some diseases, including Loeys-Dietz Syndrome 2 and Colorectal Cancer, Hereditary Nonpolyposis, Type 6.

TGFBR2 Protein (6)

    TGFBR2 Antibody (1)

      TGFBR2 cDNA Clone (52)


      TGFBR2 qPCR Primer (2)

      TGFBR2 Lysate (5)

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        TGFBR2 Background

        TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilized by a network of six intra strand disulfide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity.

        TGFBR2 References

        • Yu Y, et al. (2012) MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells. Carcinogenesis. 33(1):68-76.
        • Shima K, et al. (2011) TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers. PLoS One. 6(9):e25062.
        • Biros E, et al. (2011) Meta-analysis of the association between single nucleotide polymorphisms in TGF-β receptor genes and abdominal aortic aneurysm. Atherosclerosis. 219(1):218-23.

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