TMP21 Proteins, cDNA Clones Research Reagents

TMED10 (Transmembrane P24 Trafficking Protein 10) is a protein coding gene located on human chromosome 14q24.3. TMED10 is also known as p23, TMP21, p24d1, S31I125, Tmp-21-I, S31III125 and P24(DELTA). The human TMED10 gene encodes a 24976 Da protein containing 219 amino acids. The TMED10 protein is ubiquitously expressed in thyroid, endometrium and other tissues. Among its related pathways are Neuroscience and Pathogenic Escherichia coli infection. TMED10 is related to syntaxin binding. TMED4 is an important paralog of TMED10 gene. TMED10 is associated with some diseases, such as Alzheimer Disease.

TMP21 Protein (1)

    TMP21 cDNA Clone (65)


    TMP21 Lysate (1)

      TMP21 Background

      TMED10 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED10 attenuated TGF-beta-mediated signaling. A 20-amino acid-long region from Thr(91) to Glu(110) within the extracellular region of TMED10 was found to be crucial for TMED10 interaction with both ALK5 and TbetaRII. Synthetic peptides corresponding to this region inhibit both TGF-beta-induced Smad2 phosphorylation and Smad-dependent transcriptional reporter activity. In a xenograft cancer model, where previously TGF-beta was shown to elicit tumor-promoting effects, gain-of-function and loss-of-function studies for TMED10 revealed a decrease and increase in the tumor size, respectively. That TMED10 expression levels are the key determinant for efficiency of TGF-beta receptor complex formation and signaling.

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