TPSB2 Antibodies, cDNA Clones Research Reagents

TPSB2 (Tryptase Beta 2) is a protein coding gene located on human chromosome 16p13.3. TPSB2 is also known as TPS2, tryptaseB and tryptaseC. The human TPSB2 gene encodes a 30515 Da protein containing 275 amino acids. The TPSB2 protein is biasedly expressed in gall bladder, lung and other tissues. Among its related pathways are Measles. TPSB2 is related to serine-type endopeptidase activity and serine-type peptidase activity. TPSAB1 is an important paralog of TPSB2 gene. TPSB2 is associated with Mental Retardation, Autosomal Dominant 22.

TPSB2 Antibody (1)

    TPSB2 cDNA Clone (13)

    NM_024164.5

    TPSB2 qPCR Primer (1)

    TPSB2 Background

    Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1, and fall into two groups, α and β. β-tryptases appear to be the main isoenzymes expressed in mast cells, whereas α-tryptases predominate in basophils. Tryptase is unique in two respects: it is enzymatically active only as a heparin-stabilized tetramer, and it is resistant to all known endogenous proteinase inhibitors because of the unique arrangement of the active sites. Additionally, tryptase family genes have an intron immediately upstream of the initiator codon which separates the transcription initiation site from protein coding sequence, and this feature is characteristic of tryptases. β-tryptases existing in three isoforms (β1,β2,β3) are released in secretory granules, and have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. It has been reported that β-tryptase selectively cleaves ASM-derived eotaxin and RANTES and abrogates their chemotactic activities.

    TPSB2 References

    • Miller, J.S. et al., 1990, J. Clin. Invest. 86: 864-870.
    • Pereira, P.J. et al., 1998, Nature. 392: 306-311.
    • Pallaoro, M.et al., 1999, J. Biol. Chem. 274: 3355-3362.
    • Pang, L. et al., 2006, J. Immunol. 176: 3788-3795.

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