Ube2H Proteins, Antibodies, cDNA Clones Research Reagents

UBE2H (Ubiquitin Conjugating Enzyme E2 H) is a protein coding gene located on human chromosome 7q32.2. UBE2H is also known as GID3, UBC8, UBCH, UBCH2, and E2-20K. The human UBE2H gene encodes a 20655 Da protein containing 183 amino acids. The UBE2H protein is ubiquitously expressed in heart, adrenal and other tissues. Among its related pathways are Metabolism of proteins and Remodeling of Adherens Junctions. UBE2H is related to ligase activity and ubiquitin protein ligase binding. UBE2T is an important paralog of UBE2H gene. UBE2H is associated with Pontocerebellar Hypoplasia, Type 7.

Ube2H Protein (1)

    Ube2H Antibody (1)

      Ube2H cDNA Clone (15)

      NM_001202498.1

      In expression vector

      Ube2H Background

      UBE2H is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To deal with this complexity and to allow adequate ubiquitination in time and space, a highly sophisticated conjugation machinery has been developed. In a sequential manner, ubiquitin becomes activated by a ubiquitin-activating enzyme (E1), which then transfers the ubiquitin to a group of ubiquitin-conjugating enzymes (E2s). Next, ubiquitin-loaded E2s are interacting with ubiquitin-protein ligases (E3s) and ubiquitin is conjugated to substrates on recruitment by the E3. These three key enzymes are operating in a hierarchical system, wherein two E1s and 35 E2s have been found and hundreds of E3s have been identified in humans.

      Ube2H References

      • Sjoerd J L van Wijk, et al. (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol. 5: 317.
      • Nandi D, et al. (2006) The ubiquitin-proteasome system. Journal of biosciences. 31 (1): 137-55.

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