ULBP2 Proteins, Antibodies, cDNA Clones Research Reagents

ULBP2 (UL16 Binding Protein 2) is a protein coding gene located on human chromosome 6q25.1. ULBP2 is also known as N2DL2, RAET1H, RAET1L, NKG2DL2, and ALCAN-alpha. The human ULBP2 gene encodes a 27368 Da protein containing 246 amino acids. The ULBP2 protein is biasedly expressed in esophagus, lung and other tissues. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Metabolism of proteins. ULBP2 is related to peptide antigen binding and natural killer cell lectin-like receptor binding. RAET1L is an important paralog of ULBP2 gene.

ULBP2 Protein (3)

    ULBP2 Antibody (5)

      ULBP2 cDNA Clone (13)


      ULBP2 qPCR Primer (1)

      ULBP2 Lysate (2)

        ULBP2 Background

        NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein that belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.

        ULBP2 References

        • Cosman D. et al., 2001,Immunity 14:123-133
        • Cerwenka A., et al., 2003, Tissue Antigens 61:335-343
        • Chang,Y.T. et al., 2011, PLoS One. 6 (5):e20029

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