XCL2 Proteins, Antibodies, cDNA Clones Research Reagents

XCL2 (X-C Motif Chemokine Ligand 2) is a protein coding gene located on human chromosome 1q24.2. XCL2 is also known as SCM1B, SCYC2 and SCM-1b. The human XCL2 gene encodes a 12567 Da protein containing 114 amino acids. The XCL2 protein is broadly expressed in spleen, bone marrow and other tissues. Among its related pathways are RET signaling and Signaling by GPCR. XCL2 is related to chemokine activity. XCL1 is an important paralog of XCL2 gene.

XCL2 Protein (1)

    XCL2 Antibody (2)

      XCL2 cDNA Clone (1)


      In expression vector

      XCL2 Lysate (1)

        XCL2 Background

        XCL2 is a small cytokine belonging to the XC chemokine family. Chemokines are a group of cytokines. Members of this group of so-called C-Chemokines belong to the SCY family of cytokines and are designated XCL (L for ligand) followed by a number. XCL2 is the new designation of SCM-1-beta. XCL2 is highly related to another chemokine called XCL1. XCL2 gene is located on chromosome 1 in humans. XCL2 is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1. XCL2 gene has been proposed to participate in pathways (Chemokine signaling pathway, Cytokine-cytokine receptor interaction) and processes (blood circulation, signal transduction, chemotaxis, immune response). XCL2 are expected to have molecular function (chemokine activity) and to localize in various compartments (extracellular space, extracellular region). A putative protein interactor has been described (XCR1). The spliced mRNA putatively encodes a good protein, containing small cytokines (intecrine / chemokine), interleukin-8 like domain; the complete protein appears to be secreted.

        XCL2 References

        • Kennedy J, et al. (1995) Molecular cloning and functional characterization of human lymphotactin. J Immunol. 155(1):203-9.
        • Yoshida T, et al. (1998) Identification of single C motif-1 / lymphotactin receptor XCR. J Biol Chem. 273(26):16551-54.
        • Yoshida T, et al. (1996) Structure and expression of two highly related genes encoding SCM-1 / human lymphotactin. FEBS Lett. 395(1):82-8.

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