CD100 antigens

CD100 antigens general information

CD100 Gene ID 10507
CD100 Official Full Name semaphorin 4D
CD100 Alias Semaphorin 4D, SEMA4D
CD100 Cellular Expression T; B; NK; Granulocyte; Macrophage
CD100 Ligand/Receptor/Association CD45, CD72, plexin B
CD100 Function Enhancement of B-cell and dendritic cell responses
CD100 Summary CD100 / Cluster of Differentiation 100 also known as Semaphorin-4D (SEMA4D), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene. CD100 is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation. During skin damage repairs, CD100 interacts with Plexin B2 on gamma delta t cells to play a role in the healing process.

Information from NCBI or Wiki

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