CD108 antigens

CD108 antigens general information

CD108 Gene ID 8482
CD108 Official Full Name semaphorin 7A (John Milton Hagen blood group)
CD108 Alias Semaphorin 7A, SEMA7A
CD108 Cellular Expression T; B; Erythrocyte
CD108 Ligand/Receptor/Association CD232
CD108 Function Monocyte activator. Negative regulator of T-cell responses. Stimulates axon growth and guidance during development
CD108 Summary This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Information from NCBI or Wiki

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