Anti-Nectin-2 Antibody

Price:
Size:
Number:

Anti-Nectin-2 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-Nectin-2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Rat
Specificity
Rat Nectin-2
No cross-reactivity in ELISA with
Rat PVRL1
Immunogen
Recombinant Rat CD112 / Nectin-2 / PVRL2 protein (Catalog#80327-R08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Rat CD112 / Nectin-2 / PVRL2 (Catalog#80327-R08H; Q9ESS6; Met1-Gly351).
Source
Monoclonal Rabbit IgG Clone #013
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Nectin-2 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Nectin-2 Background Information

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
Full Name
poliovirus receptor-related 2 (herpesvirus entry mediator B)
References
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
Add to Cart Successfully Add to Cart Failed Shopping cart is being updated, please wait