CD115 antigens

CD115 antigens general information

CD115 Gene ID 1436
CD115 Official Full Name colony stimulating factor 1 receptor
CD115 Alias M-CSFR, c-fms, CSF1R
CD115 Cellular Expression Macrophage; monocytes; Stem cell
CD115 Ligand/Receptor/Association M-CSF
CD115 Function Monocytic cell proliferation and differentiation
CD115 Summary The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Information from NCBI or Wiki

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