CD11c antigens

CD11c antigens general information

CD11c Gene ID 3687
CD11c Official Full Name integrin subunit alpha X
CD11c Alias p150, 95, CR4, integrin αX, LFA-1A, ITGAX
CD11c Cellular Expression T; B; NK; Dendritic; Granulocyte; Macrophage; monocytes
CD11c Ligand/Receptor/Association iC3b, ECM
CD11c Function Cell adhesion
CD11c Summary This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Information from NCBI or Wiki

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