CD11c/ITGAX cDNA Clone: Expression and Clone Vector / Plasmid

CD11c/ITGAX cDNA / Gene Overview

ITGAX cDNA / gene is a gene with protein product which located on 16p11.2. The ITGAX gene is conserved in chimpanzee, dog, mouse, and rat. 87 organisms have orthologs with human gene ITGAX.

CD11c/ITGAX cDNA / Gene Function

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

CD11c/ITGAX cDNA / Gene Sequence

LOCUS
BC038237 4042 bp mRNA linear PRI 06-JUN-2006
DEFINITION
Homo sapiens integrin, alpha X (complement component 3 receptor 4 subunit), mRNA (cDNA clone MGC:46124 IMAGE:5745308), complete cds.
ACCESSION
BC038237
VERSION
BC038237.1

This sequence information is just for reference only.

CD11c/ITGAX Family & Reagents

CD11c/ITGAX Gene family reagents (CD molecules)

Approved Symbol Reagent list
TNFRSF17
SPN
LAIR2
TNFRSF10C
CD22
LILRA3
SDC1
LILRB5
SIRPA
TFRC
Approved Symbol Reagent list
THY1
IL6ST
KIR2DL1
NECTIN1
FCGR3A
Clec9a
CDH1
CD58
ERBB2
BMPR1A

CD11c/ITGAX Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C5
C7
CD59
CFD
CFHR1
CR2
Approved Symbol Reagent list
C2
C6
CD46
CFB
CFH
CFHR2
   

CD11c/ITGAX cDNA / Gene Alias

  • CD11c
  • complement component 3 receptor 4 subunit

CD11c/ITGAX cDNA / Gene Expression

Biased expression in spleen (RPKM 34.3), appendix (RPKM 32.4) and 12 other tissues