CD121a antigens

CD121a antigens general information

CD121a Gene ID 16177
CD121a Official Full Name interleukin 1 receptor, type I
CD121a Alias IL-1R type I, IL1R1, IL1R1, IL-1 RI
CD121a Cellular Expression T; Dendritic; Endothelial; Epithelial; Granulocyte; Macrophage; monocytes
CD121a Ligand/Receptor/Association IL-1α, IL-1β, IL-1RA
CD121a Function Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling
CD121a Summary Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.[1] The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.[1]

Information from NCBI or Wiki

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