| CD121b Gene ID | 7850 |
| CD121b Official Full Name | interleukin 1 receptor type 2 |
| CD121b Alias | IL-1R, type II, IL1R2, IL-1R2 |
| CD121b Cellular Expression | T; B; Macrophage; monocytes |
| CD121b Ligand/Receptor/Association | IL-1α, IL-1β, IL-1RA |
| CD121b Function | Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling |
| CD121b Summary | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] |
Information from NCBI or Wiki
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