CD124 antigens

CD124 antigens general information

CD124 Gene ID 3566
CD124 Official Full Name interleukin 4 receptor
CD124 Alias IL4RA, IL4R
CD124 Cellular Expression T; B; Endothelial; Epithelial; Macrophage; monocytes; Stem cell
CD124 Ligand/Receptor/Association IL-4, IL-13
CD124 Function Receptor for IL4 and IL13
CD124 Summary This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Information from NCBI or Wiki

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