CD13 antigens

CD13 antigens general information

CD13 Gene ID 290
CD13 Official Full Name alanyl aminopeptidase, membrane
CD13 Alias Aminopeptidase N, APN, ANPEP,PEPN
CD13 Cellular Expression T; Dendritic; Endothelial; Epithelial; Granulocyte; Macrophage; monocytes; Stem cell
CD13 Ligand/Receptor/Association coronavirus, CMV, L-leucyl-β-napthylamine
CD13 Function Aminopeptidase
CD13 Summary Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

Tips: We list all the CD antigens according to the specific name of CD molecules.