CD130 antigens

CD130 antigens general information

CD130 Gene ID 3572
CD130 Official Full Name interleukin 6 signal transducer
CD130 Alias IL-6Rβ, gp130, IL6ST
CD130 Cellular Expression T; B; NK; Endothelial; Epithelial; Granulocyte; Macrophage; monocytes; Stem cell
CD130 Ligand/Receptor/Association  
CD130 Function Transmits activities of IL6, IL11, LIF and CNF
CD130 Summary The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

Information from NCBI or Wiki

Tips: We list all the CD antigens according to the specific name of CD molecules.