CD14 antigens

CD14 antigens general information

CD14 Gene ID 929
CD14 Official Full Name CD14 molecule
CD14 Alias LPS-R
CD14 Cellular Expression Granulocyte; Macrophage; monocytes
CD14 Ligand/Receptor/Association LPS
CD14 Function Receptor for complex of LPS and LBP
CD14 Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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