CD142 antigens

CD142 antigens general information

CD142 Gene ID 2152
CD142 Official Full Name coagulation factor III, tissue factor
CD142 Alias Tissue Factor, F3
CD142 Cellular Expression Endothelial; Epithelial; Macrophage; monocytes
CD142 Ligand/Receptor/Association 0
CD142 Function Initiates blood clotting
CD142 Summary This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Information from NCBI or Wiki

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