CD167b antigens

CD167b antigens general information

CD167b Gene ID 4921
CD167b Official Full Name discoidin domain receptor tyrosine kinase 2
CD167b Alias DDR2
CD167b Cellular Expression  
CD167b Ligand/Receptor/Association  
CD167b Function Receptor tyrosine kinase involved in cell-cell interactions
CD167b Summary Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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