CD182 antigens

CD182 antigens general information

CD182 Gene ID 3579
CD182 Official Full Name C-X-C motif chemokine receptor 2
CD182 Alias CXCR2, IL8R2, IL8RA, IL8RB, CMKAR2, CDw128b
CD182 Cellular Expression T; NK; monocytes; neutrophils
CD182 Ligand/Receptor/Association IL-8, GRO-α, β, γ, GCP-2, NAP-2, ENA-78
CD182 Function CD182 is a member of the G-protein-coupled receptor family, and a receptor for interleukin 8 (IL8)
CD182 Summary The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Information from NCBI or Wiki

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