CD185 antigens

CD185 antigens general information

CD185 Gene ID 643
CD185 Official Full Name C-X-C motif chemokine receptor 5
CD185 Alias CXCR5, BLR1
CD185 Cellular Expression T; B; NK; Dendritic; Macrophage
CD185 Ligand/Receptor/Association CXCL13
CD185 Function Homing and cell movement
CD185 Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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