CD218b antigens

CD218b antigens general information

CD218b Gene ID 8807
CD218b Official Full Name interleukin 18 receptor accessory protein
CD218b Alias IL-18Rβ, IL18RAP
CD218b Cellular Expression T; B; NK; Dendritic; Endothelial; Macrophage; monocytes
CD218b Ligand/Receptor/Association  
CD218b Function Forms part of the receptor complex for IL18
CD218b Summary The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Information from NCBI or Wiki

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