CD224 antigens

CD224 antigens general information

CD224 Gene ID 2678
CD224 Official Full Name gamma-glutamyltransferase 1
CD224 Alias GGT1
CD224 Cellular Expression T; B; Macrophage; monocytes; Stem cell
CD224 Ligand/Receptor/Association glutathione, leukotriene C4, glutathione S-conjugates
CD224 Function Catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors, which contributes to oxidative homeostasis.
CD224 Summary The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]

Information from NCBI or Wiki

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