CD25 antigens

CD25 antigens general information

CD25 Gene ID 3559
CD25 Official Full Name interleukin 2 receptor subunit alpha
CD25 Alias Tac, p55, IL2RA
CD25 Cellular Expression T; B; NK; Dendritic; Macrophage; monocytes
CD25 Ligand/Receptor/Association IL-2
CD25 Function Receptor for IL2
CD25 Summary The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

Information from NCBI or Wiki

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