CD253 antigens

CD253 antigens general information

CD253 Gene ID 8743
CD253 Official Full Name tumor necrosis factor superfamily member 10
CD253 Alias TRAIL, Apo-2L, TL2, TNFSF10
CD253 Cellular Expression T; B; NK; Macrophage
CD253 Ligand/Receptor/Association DR4, DR5, DcR1, DcR2
CD253 Function Induces cell death by apoptosis
CD253 Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Information from NCBI or Wiki

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