CD28 antigens

CD28 antigens general information

CD28 Gene ID 12487
CD28 Official Full Name CD28 antigen
CD28 Alias TP44, T44
CD28 Cellular Expression T; NK
CD28 Ligand/Receptor/Association CD80 (B7-1), CD86 (B7-2)
CD28 Function T-cell proliferation, survival, IL-2 production, and Th2 cell development
CD28 Summary CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular). CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive (expression is independent of environmental factors). CD28 is the only B7 receptor constitutively expressed on naive T cells. Association of the TCR of a naive T cell with MHC:antigen complex without CD28:B7 interaction results in a T cell that is anergic.

Information from NCBI or Wiki

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