CD282 antigens

CD282 antigens general information

CD282 Gene ID 7097
CD282 Official Full Name toll like receptor 2
CD282 Alias TLR2
CD282 Cellular Expression Dendritic; Epithelial; Granulocyte; Macrophage; monocytes
CD282 Ligand/Receptor/Association lipoproteins, glycans
CD282 Function Mediator of innate immunity against bacterial cell wall lipoproteins. Induces activation of NFkB
CD282 Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Information from NCBI or Wiki

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