CD295 antigens

CD295 antigens general information

CD295 Gene ID 3953
CD295 Official Full Name leptin receptor
CD295 Alias LeptinR, LEPR, OB-R, Leptin Receptor
CD295 Cellular Expression T; B; NK; Dendritic; Endothelial; Epithelial; Erythrocyte; Granulocyte; Macrophage; Platelet; Stem cell
CD295 Ligand/Receptor/Association leptin
CD295 Function Receptor for leptin. Involved in the regulation of fat metabolism and required for normal lymphopoiesis
CD295 Summary Leptin receptor also known as LEP-R or OB-R is a protein that in humans is encoded by the LEPR gene.[1][2] LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 (cluster of differentiation 295).After co-discovering the Leptin gene with Jeffrey Friedman et al. in 1994, which involved a reverse genetic/positional cloning strategy to clone ob and db, Rudolph Leibel, working with collaborators at Millennium Pharmaceuticals and colleague Streamson Chua, confirmed cloning of the leptin receptor by demonstrating that an apparent leptin receptor cloned from a choroid plexus library using leptin as ligand, mapped to a physical map that included db and fa.[3]

Information from NCBI or Wiki

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