CD305 antigens

CD305 antigens general information

CD305 Gene ID 3903
CD305 Official Full Name leukocyte associated immunoglobulin like receptor 1
CD305 Alias LAIR1
CD305 Cellular Expression T; B; NK; Dendritic; Granulocyte; Macrophage; monocytes
CD305 Ligand/Receptor/Association Ep-CAM (CD326)
CD305 Function Negative regulator of NK, B, and T cells
CD305 Summary The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Information from NCBI or Wiki

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