CD321 antigens

CD321 antigens general information

CD321 Gene ID 50848
CD321 Official Full Name F11 receptor
CD321 Alias JAM-A, JAM-1, PAM-1, F11R
CD321 Cellular Expression T; B; NK; Endothelial; Epithelial; Erythrocyte; Granulocyte; Macrophage; Platelet
CD321 Ligand/Receptor/Association PAR3, LFA-1, reovirus
CD321 Function Plays a role in epithelial tight junction formation, regulation of leukocyte erythrocytes. migration, epithelial barrier maintenance and platelet activation
CD321 Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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