CD369 antigens

CD369 antigens general information

CD369 Gene ID 64581
CD369 Official Full Name C-type lectin domain family 7 member A
CD369 Alias DECTIN-1, CLECSF12, CLEC7A
CD369 Cellular Expression Macrophages; dendritic
CD369 Ligand/Receptor/Association β-1,3-linked and β-1,6-linked glucans
CD369 Function cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response
CD369 Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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