Anti-CD64 Antibody (FITC) (Rabbit Monoclonal antibody) General Information
Anti-CD64 Antibody (FITC)
Reacts with: Human
Recombinant Human CD64/Fc gamma RI Protein (Catalog#10256-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD64/Fc gamma RI (rh CD64/Fc gamma RI; Catalog#10256-H08H; NP_000557.1; Met1-Pro288) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Monoclonal Rabbit IgG Clone #407
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
10 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Flow cytometric analysis of Human CD64 expression on human whole blood monocytes. Cells were stained with FITC-conjugated anti-Human CD64. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Anti-CD64 Antibody (FITC): Alternative Names
Anti-CD64 Antibody; Anti-Fc gamma RI Antibody
CD64 Background Information
High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membraneglycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of asignal peptidethat allows its transport to the surface of a cell, threeextracellularimmunoglobulin domainsof the C2-type that it uses to bind antibody, a hydrophobictransmembrane domain, and a short cytoplasmic tail. CD64 isconstitutivelyfound on only macrophages and monocytes, but treatment of polymorphonuclear leukocyteswith cytokines likeIFNγandG-CSFcan induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.
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