CD97 antigens

CD97 antigens general information

CD97 Gene ID 976
CD97 Official Full Name adhesion G protein-coupled receptor E5
CD97 Alias ADGRE5
CD97 Cellular Expression T; B; NK; Dendritic; Granulocyte; Macrophage; monocytes
CD97 Ligand/Receptor/Association CD55, chondroitin sulfates
CD97 Function Neutrophil migration, cell adhesion and signaling
CD97 Summary This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

Information from NCBI or Wiki

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