The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
IL20RA cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Interleukin 2 receptor, alpha subunit (IL2RA/IL-2RA) also known as IL-2 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-2 receptor I, and interleukin-2 receptor subunit alpha, is a subunit for the interleukin-2 receptor. IL2RA/IL-2RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 2 (IL2), a cytokine that may be involved in epidermal function. The receptor of IL2 is a heterodimeric receptor complex consisting of this protein and interleukin 2 receptor beta (IL2B). IL2RA forms heterodimer with IL2RB, and the complex serves as a receptor for IL19, IL2 and IL24. All three are capable of signaling through IL-2RA/IL-2RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition, IL2RA also forms a heterodimer with the unique and specific receptor IL1RB and functions as the receptor for IL26. IL2RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL2RA and IL2RB is found to be upregulated in psoriatic skin lesions on keratinocytes.
interleukin 20 receptor, alpha
Parrish-Novak J, et al. (2002) Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 277(49): 47517-23.
Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5): 445-51.
Blumberg H, et al. (2001) Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 104(1): 9-19.
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