Cluster of differentiation in NK cell

In humans, there are several stages of NK development in the bone marrow, which are based on the expression levels of CD34, CD117, CD56 and CD94. These phenotypes are restricted to the bone marrow and are not found in lymph nodes, spleen or peripheral blood. NK maturation begins with the expression of CD56 followed by simultaneous expression of CD94/NKG2A. Final NK maturation in the bone marrow correlates with a reduction in CD94/NKG2A expression and a CD56 low phenotype. It has been proposed that stage 2 cells, which are precursor NK cells, can traffic to lymphnodes, spleen and peripheral blood where they can undergo further but restricted maturation. Further details of marker expression during the different stages of development can be seen in table 1. NK cell developmental stages in human bone marrow. Also crucial to the development of NK cells from common precursors is the expression of CD122.

NK cell receptors in humans (H) and mice (M)

CD antigens of NK cell adhesion receptor

Receptor Alias Species Class Ligand
CD2 T11, LFA-2, SRBC-R, Erythrocyte receptor, LFA-3R H, M IgSF CD48, CD58
CD11a LFA-1, LFA1A, ITGAL H, M IgSF CD54, CD102
CD43 Leukosialin, sialophorin, SPN H, M IgSF
CD44 H-CAM, Pgp-1, Epican, HUTCH-I, LHR, ECMR-III H, M IgSF Hyaluronic acid
CD49b VLA-2, ITGA2 M IgSF
CD56 NCAM1 H IgSF
CD223 LAG-3 H IgSF HLA class II

CD antigens of NK cell adhesion receptor

Receptor Alias Species Class Ligand
CD16a FcγRIIIA, FCGR3A, FCG3, FCGR3, IGFR3 H, M IgSF Immune complexes
CD16b FcγRIIIB, FCGR3B, FCG3, FCGR3, IGFR3 H, M IgSF Immune complexes
CD27 T14, TNFRSF 7, CD27L receptor H, M TNFRSF CD70
CD28 TP44, T44 H, M IgSF CD80, CD86
CD69 AIM, CLEC2C, EA1 H, M C-lectin
CD122 IL-2Rβ, IL-2RB H, M CytoR IL-2, IL-15
CD161 NKR-P1A, KLRB1 H, M C-lectin Clr-g (NKR-P1F)
CD226 DNAM-1, PTA-1, TLiSA1 H IgSF CD112, CD155
CD244 2B4, NAIL H, M SLAM CD48
CD314 NKG2D, KLRK1 H, M C-lectin MICA, B, ULBs (H)
CD336 NKp44, Ly-95 homolog, NCR2 H, M IgSF
CD337 NKp30, Ly117, NCR3 H, M IgSF

CD antigens of NK cell inhibitory receptor

Receptor Alias Species Class Ligand
CD85a LILRB3, ILT5, LIR3 H IgSF HLA-A, -B, -G
CD161 NKR-P1A, KLRB1 M C-lectin Clr-b (NKR-P1D)
CD244 2B4, NAIL H,M SLAM CD48