colony-stimulating-factor-(csf)---receptor
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집락자극인자(CSF) 및 수용체

Proteins

Colony-stimulating factors (CSFs) are secreted glycoproteins which regulate bone marrow production of circulating red and white cells, and platelets. Colony-stimulating factors bind to receptors on the surfaces of hemopoietic stem cells and thereby activate intracellular signaling pathways which induce the cells to proliferate and differentiate into a specific kind of blood cell. Colony-stimulating factors include: macrophage colony-stimulating factor (M-CSF), Granulocyte macrophage colony-stimulating factor (GM-CSF) and Granulocyte colony-stimulating factor (G-CSF).

Sino Biological offers a comprehensive set of tools for research on colony-stimulating factors (CSFs) and their receptors, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, rabbit pAbs), ELISA kits, and ORF cDNA clones.

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집락자극인자(CSF) 및 수용체

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Colony-stimulating factors (CSFs) are secreted glycoproteins which regulate bone marrow production of circulating red and white cells, and platelets. Colony-stimulating factors bind to receptors on the surfaces of hemopoietic stem cells and thereby activate intracellular signaling pathways which induce the cells to proliferate and differentiate into a specific kind of blood cell. Colony-stimulating factors include: macrophage colony-stimulating factor (M-CSF), Granulocyte macrophage colony-stimulating factor (GM-CSF) and Granulocyte colony-stimulating factor (G-CSF).

Sino Biological offers a comprehensive set of tools for research on colony-stimulating factors (CSFs) and their receptors, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, rabbit pAbs), ELISA kits, and ORF cDNA clones.

집락자극인자(CSF) 및 수용체 Protein Background

Colony-stimulating factors (CSFs), also called haematopoietic growth factors, are secreted glycoproteins which regulate bone marrow production of circulating red and white cells, and platelets. Colony-stimulating factors bind to receptor proteins on the surfaces of hemopoietic stem cells and thereby activate intracellular signaling pathways which can cause the cells to proliferate and differentiate into a specific kind of blood cell. Colony-stimulating factors include: macrophage colony-stimulating factor (M-CSF), Granulocyte macrophage colony-stimulating factor (GM-CSF) and Granulocyte colony-stimulating factor (G-CSF). The M-CSF is secreted to stimulate hemopoietic stem cells to differentiate into macrophages or other related cell types. M-CSF appears to play a major role in promoting and maintaining reservoirs of human immunodeficiency virus type 1 (HIV-1) in infected individuals. GM-CSF is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. G-CSF is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release the produced cells into the blood.